Cytotoxic and Biomolecular Study of Five Plant Extracts Against Different Human Cancer Cell Lines // GP // Prof. Ayman Diab // Dr. Gehan Safwat // Dr. Salwa El-Hallouty (2017-2018)
Ezzeldin Nasser Elhawary 154093
Cytotoxic and Biomolecular Study of Five Plant
Extracts Against Different Human Cancer Cell
Lines // GP // Prof. Ayman Diab // Dr. Gehan Safwat // Dr. Salwa El-Hallouty (2017-2018) الدراسة السمية والجزيئية للخاليا من خمس مستخلصات نباتية ضد خطوط الخاليا السرطانية البشرية المختلفة - Giza MSA 2018 - 74 P. 30 CM. - BIOTECHNOLOGY DISTINGUISHED PROJECTS 2018 .
Biotechnology
Natural products offer a wide variety of chemical structures
with different biological activities that can be used for the
development of novel drugs. Around 60% of the current
anticancer drugs were isolated from natural products. In this study, it is attempted
to exploit five plant extracts, Euphorbia hierosolymitana (herb), Sapium sebifera
(branch), Cordyline fruticosa (leaf and branch), Dracerna marginata (bark) and
Dracaena marginata (leaf and branch), and show their cytotoxic activities on
different human cancer cell line including breast carcinoma (MCF-7), hepatocellular
carcinoma (HepG2), colon carcinoma (HCT116) and prostate cancer (PC3), and
normal skin cell line (BJ-1). Methanol extracts of these plants underwent MTT
cytotoxic assay and found that E. hierosolymitana selectively inhibited HCT116 cell
proliferation with IC50 of 4.22 μg/ml, both Dracaena marginata extracts showed
moderate cytotoxicity on MCF-7 with IC50 of 22.4 and 48.2 μg/ml, respectively. The
remaining two extracts showed minimal to insignificant percentage inhibition on all
--Medical Biotechnology
Biomolecular
Cytotoxic
Biotechnology
612
Cytotoxic and Biomolecular Study of Five Plant
Extracts Against Different Human Cancer Cell
Lines // GP // Prof. Ayman Diab // Dr. Gehan Safwat // Dr. Salwa El-Hallouty (2017-2018) الدراسة السمية والجزيئية للخاليا من خمس مستخلصات نباتية ضد خطوط الخاليا السرطانية البشرية المختلفة - Giza MSA 2018 - 74 P. 30 CM. - BIOTECHNOLOGY DISTINGUISHED PROJECTS 2018 .
Biotechnology
Natural products offer a wide variety of chemical structures
with different biological activities that can be used for the
development of novel drugs. Around 60% of the current
anticancer drugs were isolated from natural products. In this study, it is attempted
to exploit five plant extracts, Euphorbia hierosolymitana (herb), Sapium sebifera
(branch), Cordyline fruticosa (leaf and branch), Dracerna marginata (bark) and
Dracaena marginata (leaf and branch), and show their cytotoxic activities on
different human cancer cell line including breast carcinoma (MCF-7), hepatocellular
carcinoma (HepG2), colon carcinoma (HCT116) and prostate cancer (PC3), and
normal skin cell line (BJ-1). Methanol extracts of these plants underwent MTT
cytotoxic assay and found that E. hierosolymitana selectively inhibited HCT116 cell
proliferation with IC50 of 4.22 μg/ml, both Dracaena marginata extracts showed
moderate cytotoxicity on MCF-7 with IC50 of 22.4 and 48.2 μg/ml, respectively. The
remaining two extracts showed minimal to insignificant percentage inhibition on all
--Medical Biotechnology
Biomolecular
Cytotoxic
Biotechnology
612