Abanoub Kasban Amen 151381

Antihyperglycemic activity evaluation and chemical profiling of edible pericarps of phaseolus vulgaris L
RSPHO 1.1 // GP // Prof. Dr. Amany El-Brairy // A.L. MahaMousa Mahmoud (2018 - 2019) - Giza : MSA, 2019. - 61 p. - PHARMACY DISTINGUISHED PROJECTS 2019 .

Pharmacy - Pharmacology

Diabetes is considered a serious metabolic disorder characterized by hyperglycemia due to absolute
insulin deficiency or complete destruction of pancreatic beta cells (Type 1 diabetes) and beta cells
receptors resistance (Type 2 DM). Diabetes complications are peripheral vascular diseases, coronary
vascular diseases and sexual dysfunction. Conventional drugs cause adverse effects and have high cost.
Nowadays, herbal drugs are used due to their natural origin and affordable cost. The study aims to
evaluate the antidiabetic activity of phaseolusvulgare L pericarps. Diabetes was induced through a single
IP injection of 55 mg /kg of STZ and rats was randomly divided into 6 groups each contain 6 rats Group
1: Normal control (received saline), Group 2: Diabetic control, Group 3: Diabetic group received
standard drug glibenclamide (600 ug /kg P.O.) , Group 4: Diabetic group received non polar fraction of
phaseolus vulgaris extract (200 mg P.O.), Group 5: Diabetic group received MSCs ( 106 cell /rat IP ) and
Group 6 : Diabetic group received both NPF phaseolus vulgaris and MSCs. Phaseolus vulgaris
significantly decreases glucose level , MDA, cholesterol and TGs (P<0.005) and significantly increases
insulin level , Nitric oxide (NO) and HDL (P<0.005).While stem cells group significantly decreases
glucose level, MDA (P<0.005) and slight decrease in cholesterol and no significant decrease in TGs
.Combined group shows low glucose & MDA level and increase in insulin , nitric oxide and HDL level .
The study showed that NPF phaseolus vulgaris (200mg /kg), stem cells and combined have antidiabetic