Fusion Gene Transcripts t(12:21) ETV6 RUNXI And t(1;19) TCF3-PBXI In pediatric Acute Lymphoblastic Leukemia (All) اندماج الجينات 1 اللوكيميا اللمفاوية الحادة للأطفال / GP/ DR. Ayman Diab ( 2017-2018) (Record no. 13752)
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| fixed length control field | 02376nam a22002177a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190306174822.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180215b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | MSA |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Germine amr Attif. 153573 |
| 245 ## - TITLE STATEMENT | |
| Title | Fusion Gene Transcripts t(12:21) ETV6 RUNXI And t(1;19) TCF3-PBXI In pediatric Acute Lymphoblastic Leukemia (All) اندماج الجينات 1<br/>اللوكيميا اللمفاوية الحادة للأطفال / GP/ DR. Ayman Diab ( 2017-2018) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2017. |
| Place of publication, distribution, etc. | Giza: |
| Name of publisher, distributor, etc. | MSA, |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 75P. :, |
| Other physical details | 26 CM. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Title | Biotechnology DISTINGUISHED PROJECTS 2017 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer malignancies are caused by the acquisition of somatic<br/>mutations that act with hereditary genetic variations initiating<br/>the development of malignant tumors by disrupting the cell’s<br/>normal machinery. They are caused by mainly three genetic<br/>events: copy number alteration,<br/>mutations, and translocations. In general, leukemia is considered the most<br/>prevalent malignancy affecting children and accounts for one-third of all pediatric<br/>malignant tumors. Moreover, three-quarters of the diagnosed childhood leukemia<br/>are of ALL type, which is the proliferation of malignant lymphatic cells whose<br/>differentiation was stopped at an early stage. The aim of this project was to test for<br/>the presence of two translocations t(12;21) and t(1;19), yielding the two fusion<br/>genes ETV6-RUNX1 and TCF3-PBX1 respectively, in 27 samples of newly diagnosed<br/>B-ALL patients in Children Cancer Hospital (57357), for the subsequent risk<br/>stratification of these patients. This was done by using the molecular technique RTPCR,<br/>by first extracting the RNA from the samples then converting it into cDNA,<br/>then amplifying the housekeeping gene ABL to determine the quality of the<br/>processed samples, and finally amplifying the two translocations using the<br/>conventional PCR methods. The results have shown that 2 patients harbored the<br/>translocation t(12;21) and 3 other patients carried the translocation t(1;19),<br/>expressing a frequency rate that contradicts the normally reported ones |
| 630 ## - SUBJECT ADDED ENTRY--UNIFORM TITLE | |
| Form subdivision | Medical Biotechnology |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Gene Transcripts. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | DR. Dina Yassin. |
| Relator term | Etrenal Supervisor. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://drive.google.com/file/d/11MoPDNzcvNgifSBA9Qwbh2m2RlCIaj44/view?usp=sharing">https://drive.google.com/file/d/11MoPDNzcvNgifSBA9Qwbh2m2RlCIaj44/view?usp=sharing</a> |
| Public note | FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Gradution Project |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Total Renewals | Full call number | Barcode | Date last seen | Date last checked out | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Centeral Library | Centeral Library | Soft Copy located on library Cataloge | 15.02.2018 | 1 | 1 | GP266 BIO 2017 | 81781 | 03.06.2018 | 30.04.2018 | 15.02.2018 | Distinguished Graduation Projects |