MARC details
| 000 -LEADER |
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| fixed length control field |
02773nam a22002657a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20190722080733.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190720b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
615.1 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Ahmed Mohamed Gamal 150907 |
| 245 ## - TITLE STATEMENT |
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| Title |
Formulation and characterization of novel supermagnetic solid lipid nanostructure lipid carrier in situ nasal gel for Zolmitriptan brain targeting // GP // Dr. Dalia Abdel Aty // A.L. Al-Shaimaa Shaaban (2018 - 2019) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Giza : |
| Name of publisher, distributor, etc. |
MSA, |
| Date of publication, distribution, etc. |
2019. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
49 p. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
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| Title |
Pharmacy distinguished Projects 2019 |
| 500 ## - GENERAL NOTE |
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| General note |
Pharmacy - Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Nanotechnology development started from 20th century. It has the ability to deliver a small<br/>molecular weight drugs also the ability to targeting to cells and tissues by macromolecules such<br/>as genes, peptides and proteins. A lot of problems are solved by the use of nanotechnology like<br/>lipophilic drugs by formulating them as nanoparticles, poorly soluble drugs by decreasing the<br/>drug reactions and improving bioavailability. Solid lipid nanoparticles (SLNs) are defined as<br/>colloidal particles which is characterized by small particle size, ability to change surface<br/>properties and large surface area that facilitates the bioavailability of poorly water soluble<br/>molecules also improving the penetration of the drug into the skin and providing the stability.<br/>Magnetic nanoparticles (MNPs) are a special type of NPs that is characterized by high magnetic<br/>susceptibility which validate it to be used in biomedical application. The particle size should be<br/>small and the MNPs must have a high magnetization to facilitate its motion in the blood vessels<br/>with an external magnetic field. Zolmitriptan is a selective serotonin receptor agonist which is<br/>effective in reducing migrane symptoms. The purpose of the study is to prepare supermagnetic<br/>solid lipid nanostructure lipid carrier of Zolmitriptan to enhance its bioavailability and to develop<br/>SLNs containing Zolmitriptan. The objectivities are achieving maximum bioavailability,<br/>achieving better solubility and achieving controlled sustained release of the drug. In this study, 6<br/>formulas were prepared with different ratios and were evaluated for their particle size with a<br/>range of (205.8_ 469.5 d.nm) and zeta potential with a range of (-14.0_ -20 mv) and the<br/>entrapment efficiency were (58%_55%).Formula number 4 were the best as it had the slowest<br/>release. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Nanotechnology |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
lipid nanostructure |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Hossam Mohamed Mahmoud 153147 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Nada Ahmed Abd El-Khalek 150129 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sohila Khaled Ahmed Mohamed 150673 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://qrgo.page.link/PKrd1">https://qrgo.page.link/PKrd1</a> |
| Public note |
FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Distinguished Graduation Projects |
