Design, synthesis and biological activity of semisynthetic phenolic acid analogues // GP //Dr. Amal Ali // T.A. Sara El. Sayed (2018 - 2019) (Record no. 24942)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02214nam a22002537a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190908095547.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190721b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 547 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mena Samy Moris 150205 |
| 245 ## - TITLE STATEMENT | |
| Title | Design, synthesis and biological activity of semisynthetic phenolic acid analogues // GP //Dr. Amal Ali // T.A. Sara El. Sayed (2018 - 2019) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Giza: |
| Name of publisher, distributor, etc. | MSA, |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 55 P. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Title | PharmaciesDISTINGUISHED PROJECTS 2019 |
| 500 ## - GENERAL NOTE | |
| General note | Pharmacy - Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Ferulic acid (4- hydroxy-3-methoxycinnamic acid) is derived from natural source,<br/>consequently it has low Toxicity. It is one of the most abundant phenolic acids in plants.<br/>Ferulic acid has shown anticancer activity in various types of cancers. Large amounts of<br/>hydrogen peroxide are produced and secreted by tumour cells, which are responsible for<br/>spreading and invasion of the tumour. Anti-cancer activity of Ferulic Acid is related to its<br/>antioxidant property by inhibition of oxidative enzyme, enhancement of cytoprotective<br/>enzymes and acting as free radical scavenger. Ferulic acid structure has phenolic ring which<br/>act as free radical scavenger by its hydrogen donating ability. The presence of p-hydroxyl<br/>groups in aromatic ring, meta methoxy group and conjugated double bond are essential for<br/>activity. The aim of the project is to design and synthetize ferulic acid derivatives with<br/>potential anticancer activity. The amide derivatives of ferulic acid were synthetized by the<br/>reaction between ferulic acid and the different amines using DCC and THF. Purification of<br/>the compounds was done using column chromatography which is conducted by the<br/>pharmacognosy department and characterization was done using IR spectroscopy and proton<br/>NMR. Compounds were screened for anticancer activity against caco cell lines where they<br/>showed a significant anticancer activity |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | semisynthetic phenolic |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bassant Khaled Ragheb 151623 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Mohamed Abdel Hady 154547 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ismail Saeid 151275 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://qrgo.page.link/wBiUJ">https://qrgo.page.link/wBiUJ</a> |
| Public note | FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Distinguished Graduation Projects |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Centeral Library | Centeral Library | Soft Copy located on library Cataloge | 21.07.2019 | GP32PH2019 - OCHEM | 82023 | 21.07.2019 | 21.07.2019 | Distinguished Graduation Projects |