MARC details
| 000 -LEADER |
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| fixed length control field |
02597nam a22002657a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20190722082453.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190722b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
543 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Madonna Shaheer Asaad 152057 |
| 245 ## - TITLE STATEMENT |
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| Title |
Chromatographic quantification of drug residues in food of animal origin // GP // Dr. Dalia Mohamed Mamdouh // T.A. Amira Ismael (2018 - 2019) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Giza : |
| Name of publisher, distributor, etc. |
MSA, |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
65 P. |
| 500 ## - GENERAL NOTE |
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| General note |
Pharmacy - Pharmaceutical Analytical Chemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Nowadays, livestock marketed products represent forty percent of the daily diet. Meanwhile,<br/>veterinary drugs are also widely used for diverse intentions, including maintaining health and<br/>improving feed efficiency of animals. However, the most used class of veterinary drugs is<br/>antibiotics including Trimethoprim (TMP) and Sulfadiazine (SDZ). The overdosing or the<br/>sudden stop of these agents causes the accumulation of drug residue in different animal.<br/>Subsequently, consumption of livestock products containing such residues may impose<br/>negative effects on human health. Consequently, the present work is devoted to the<br/>development of sensitive HPLC-UV methods for the quantitative estimation of TMP and SDZ<br/>in chicken muscles. In method 1; the drugs were extracted using methanol. Chromatographic<br/>separation was accomplished on a C18 column and mobile phase of water: ethanol (90: 10 v/v)<br/>pH = 5.5 using 0.1N acetic acid. The UV detection was at 230 nm and 280 nm for TMP and<br/>SDZ, respectively. The method was linear in the range of 0.5-50 μg/mL and 0.5-60 μg/mL for<br/>TMP and SDZ, respectively. In method 2 (Micellar Chromatography); 0.1 M SDS was used to<br/>extract the two drugs. Chromatographic separation was performed on Xterra C18 column and<br/>mobile phase composed of 0.1M SDS: acetonitrile (90: 10 v/v) pH = 5.5 with 0.1 N citric acid.<br/>The UV detection was 254 nm. The developed method was linear in the range of 0.5-100 μg/mL<br/>for both drugs. The obtained recoveries in the spiked chicken samples were found satisfactory.<br/>The developed HPLC-UV methods were validated in accordance to the ICH guidelines proving<br/>the methods to be accurate, precise and selective. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Chromatographic quantification |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Analytical Chemistry |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Pharmaceutical |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mariam Ayman Emile 151025 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Marina Badr Amin 151055 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Pakinam Ahmed Mohamed 150307 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1cbsLkMqqdg1ud1q6hjNdeU6sU0d9Re2h/view">https://drive.google.com/file/d/1cbsLkMqqdg1ud1q6hjNdeU6sU0d9Re2h/view</a> |
| Public note |
FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Distinguished Graduation Projects |
