35986841_10216840653711318_1105697261150535680_n

Enhancement of Eplerenone Dissolution Rate via Sonoprecipitation: Formulation, Evaluation, Analysis and Stability Testing // GP // Dr. Ghada Ehab Yassin // T.A. Radwa El-Masry (2018 - 2019) (Record no. 24945)

000 -LEADER
fixed length control field 02639nam a22002417a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190722083835.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190722b ||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency MSA
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Sally Saied Ahmed Elnaggar 151175
245 ## - TITLE STATEMENT
Title Enhancement of Eplerenone Dissolution Rate via Sonoprecipitation: Formulation, Evaluation, Analysis and Stability Testing // GP // Dr. Ghada Ehab Yassin // T.A. Radwa El-Masry (2018 - 2019)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Giza:
Name of publisher, distributor, etc. MSA,
Date of publication, distribution, etc. 2019.
300 ## - PHYSICAL DESCRIPTION
Extent 62 P.
500 ## - GENERAL NOTE
General note Pharmacy - Pharmaceutics
520 ## - SUMMARY, ETC.
Summary, etc. Eplerenone is a selective mineralocorticoid receptor antagonist. It is used as an oral<br/>antihypertensive drug, it has very low solubility in water as according to (BCS) it belongs to<br/>Class II. This study aims to improve the solubility of poorly water-soluble eplerenone by using<br/>sonoprecipitation technique to increase the dissolution rate. Improving solubility of eplerenone<br/>is done by making eplerenone sonocrystal formulation to form a uniform and spherical shape of<br/>microcrystals using probe sonicator, followed by evaluation of the prepared sonocrystals by<br/>particle size measurement using zetasizer, Fourier transform infrared (FTIR) to determine the<br/>interaction between stabilizers (Poloxamer 188 and polyethylene glycol 6000) and drug<br/>sonocrystals, differential scanning calorimetry (DSC) to observe the changes occurred in<br/>eplerenone during spherical formulation process while X-ray diffraction (XRD) to obtain<br/>diffraction patterns for eplerenone, physical mixture, and formulations. The determination of<br/>drug content for the prepared soncrocrystal formulations was also performed. In addition, the<br/>drug release of the prepared formulae was studied and compared to pure eplerenone by in vitro<br/>dissolution. Results show that particle size range from 132nm to 455nm, FTIR and DSC shows<br/>that there’s no interaction between stabilizers and drug sonocrystals while XRD indicates the<br/>change of the drug into amorphous leading to increase the solubility, the dissolution rate was<br/>improved for all the formulations when compared with pure eplerenone. Therefore, it is<br/>concluded that the sonoprecipitation technique could be a useful technique to improve the<br/>solubility of eplerenone with a reduction in particle size, and enhanced dissolution properties.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Eplerenone
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Sonoprecipitation
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Fatma Mahmoud Saleh 150915
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mayar Ayman Sabry 151827
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mona Abdalla Omran 150921
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1yIqVO95Dg7Ge_bFgMz9TB7mAuP6H8BVp/view">https://drive.google.com/file/d/1yIqVO95Dg7Ge_bFgMz9TB7mAuP6H8BVp/view</a>
Public note FULL TEXT PRESS HERE
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Distinguished Graduation Projects
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Full call number Barcode Date last seen Price effective from Koha item type
          Centeral Library Centeral Library Soft Copy located on library Cataloge 2019-07-22 GP32PH2019 - Ceutics 82026 2019-07-22 2019-07-22 Distinguished Graduation Projects