MARC details
000 -LEADER |
fixed length control field |
02374nam a22002417a 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190727104138.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190727b ||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Transcribing agency |
MSA |
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
615.19 |
100 ## - MAIN ENTRY--PERSONAL NAME |
Personal name |
Mariam Akram El-Meligy 151019 |
245 ## - TITLE STATEMENT |
Title |
NANO-FORMULATION AND PHARMACOLOGICAL EVALUATION OF <br/>ANTI-AGING HERBAL PRODUCTS // GP //Dr. Mahitab Helmi (2018 - 2019 ) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Giza |
Name of publisher, distributor, etc. |
MSA |
Date of publication, distribution, etc. |
2019 |
300 ## - PHYSICAL DESCRIPTION |
Extent |
70 |
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
Pharmacy DISTINGUISHED PROJECTS 2019 |
500 ## - GENERAL NOTE |
General note |
Pharmacy |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Wrinkles are creases, folds, or ridges in the skin. After the age of 20, the skin begins to lose over time its elasticity, firmness and collagen fibers. Accordingly, wrinkles tend to occur in the areas of muscle contraction. Citrus sinensis L. belonging to family Rutaceae are widely consumed in Egypt. Citrus peels are the most important by-product of Citrus fruits. They are major sources of phenolics specially flavanones and their glycosides, which are a powerful natural antioxidant that may possess an anti-wrinkles activity. The aim of this project is to characterize the major metabolites in the 95% ethanolic extract of C. sinensis fruits peels and evaluate its antioxidant and anti-wrinkles activities. The HPLC analysis of the extract revealed that the major compounds were hesperidin and quercetin. The extract was characterized also via HPLC-MS-MS, the analysis revealed that sesamolinol and hesperidin were the major identified constituents. The antioxidant activity was evaluated using ORAC assay and the extract showed promising antioxidant activity. The in vitro anti-wrinkles activity of the extract was evaluated by screening their inhibitory activity on elastase and collagenase enzymes, the extract showed good inhibitory activity with IC50 values of 299.04 ug/ml and 188.6lug/ml respectively, which is close to the tested standards Elafin and EGCG (IC50 250.09 and 112.12 ug/ml). Thus, C. sinensis fruits peels extract can be used to develop a completely natural anti-aging herbal product with antioxidant <br/> |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
NANO-FORMULATION |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
ANTI-AGING HERBAL PRODUCTS |
700 ## - ADDED ENTRY--PERSONAL NAME |
Relator code |
Sara Ishaq Bolis 150171 |
-- |
Sherine Bahaa El-Dein 150929 |
-- |
Taghreed Sameh Mahdy 150791 |
856 ## - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1TkSDjuZnh_-owL_JpkEoG1wkyANMiFog/view">https://drive.google.com/file/d/1TkSDjuZnh_-owL_JpkEoG1wkyANMiFog/view</a> |
Public note |
FULL TEXT PRESS HERE |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
Dewey Decimal Classification |
Koha item type |
Distinguished Graduation Projects |