35986841_10216840653711318_1105697261150535680_n

NANO-FORMULATION AND PHARMACOLOGICAL EVALUATION OF ANTI-AGING HERBAL PRODUCTS // GP //Dr. Mahitab Helmi (2018 - 2019 ) (Record no. 24959)

MARC details
000 -LEADER
fixed length control field 02374nam a22002417a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190727104138.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190727b ||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency MSA
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.19
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Mariam Akram El-Meligy 151019
245 ## - TITLE STATEMENT
Title NANO-FORMULATION AND PHARMACOLOGICAL EVALUATION OF <br/>ANTI-AGING HERBAL PRODUCTS // GP //Dr. Mahitab Helmi (2018 - 2019 )
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Giza
Name of publisher, distributor, etc. MSA
Date of publication, distribution, etc. 2019
300 ## - PHYSICAL DESCRIPTION
Extent 70
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE
Title Pharmacy DISTINGUISHED PROJECTS 2019
500 ## - GENERAL NOTE
General note Pharmacy
520 ## - SUMMARY, ETC.
Summary, etc. Wrinkles are creases, folds, or ridges in the skin. After the age of 20, the skin begins to lose over time its elasticity, firmness and collagen fibers. Accordingly, wrinkles tend to occur in the areas of muscle contraction. Citrus sinensis L. belonging to family Rutaceae are widely consumed in Egypt. Citrus peels are the most important by-product of Citrus fruits. They are major sources of phenolics specially flavanones and their glycosides, which are a powerful natural antioxidant that may possess an anti-wrinkles activity. The aim of this project is to characterize the major metabolites in the 95% ethanolic extract of C. sinensis fruits peels and evaluate its antioxidant and anti-wrinkles activities. The HPLC analysis of the extract revealed that the major compounds were hesperidin and quercetin. The extract was characterized also via HPLC-MS-MS, the analysis revealed that sesamolinol and hesperidin were the major identified constituents. The antioxidant activity was evaluated using ORAC assay and the extract showed promising antioxidant activity. The in vitro anti-wrinkles activity of the extract was evaluated by screening their inhibitory activity on elastase and collagenase enzymes, the extract showed good inhibitory activity with IC50 values of 299.04 ug/ml and 188.6lug/ml respectively, which is close to the tested standards Elafin and EGCG (IC50 250.09 and 112.12 ug/ml). Thus, C. sinensis fruits peels extract can be used to develop a completely natural anti-aging herbal product with antioxidant <br/>
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element NANO-FORMULATION
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element ANTI-AGING HERBAL PRODUCTS
700 ## - ADDED ENTRY--PERSONAL NAME
Relator code Sara Ishaq Bolis 150171
-- Sherine Bahaa El-Dein 150929
-- Taghreed Sameh Mahdy 150791
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1TkSDjuZnh_-owL_JpkEoG1wkyANMiFog/view">https://drive.google.com/file/d/1TkSDjuZnh_-owL_JpkEoG1wkyANMiFog/view</a>
Public note FULL TEXT PRESS HERE
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Distinguished Graduation Projects
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     Centeral Library Centeral Library Soft Copy located on library Cataloge 27.07.2019   GP66PH2019Pharmacognosy 82045 27.07.2019 27.07.2019 Distinguished Graduation Projects