MARC details
000 -LEADER |
fixed length control field |
02996nam a22002537a 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190728120708.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
180715b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Transcribing agency |
MSA |
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
615.704 |
100 ## - MAIN ENTRY--PERSONAL NAME |
Personal name |
Lojaine Hesham Fawzy 150249 |
245 ## - TITLE STATEMENT |
Title |
Assessment of Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients : Incidence, Risk Factors, and Prevention RS502 RSPL2.1 // GP // Prof. Dr. Soheir Aboelazm Diab // T.A. Mennat Allah Hassan Kamal (2018 - 2019) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Giza : |
Name of publisher, distributor, etc. |
MSA, |
Date of publication, distribution, etc. |
2019. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
50 p. |
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
PHARMACY DISTINGUISHED PROJECTS 2019 |
500 ## - GENERAL NOTE |
General note |
Pharmacy - Clinical Pharmacy |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Background: Anthracycline-based chemotherapy has played a significant role in the<br/>treatment of various breast cancer stages with reduced rates of both relapse and mortality.<br/>However their benefits have been limited due to their adverse events ranging from<br/>myelosuppression to well-established risk of cardiotoxicity.<br/>Aim: Investigate the correlation between incidence of cardiotoxicity and risk factors in breast<br/>cancer patients treated with Anthracyclines and outline current strategies for prevention of<br/>Anthracycline induced cardiotoxicity.<br/>Subjects and Method: 60 breast cancer patients, (stages II&IIIA), with age ranging from 30<br/>to 65 years, newly diagnosed and scheduled for chemotherapy .Our study population were<br/>classified into group 1 (30 patients receiving Anthracycline-based chemotherapy) and group 2(<br/>30 patients receiving Trastuzumab combined with anthracycline-based chemotherapy).<br/>Parameters to be measured: ejection fraction, blood pressure, body mass index, and baseline<br/>heart rate to record any case of Heart Failure (HF) following anthracyclines treatment.<br/>Results: The main comorbidities related to cardiotoxicity among study population were<br/>hypertension (44%), diabetes (31%), obesity (90%), and age above 55 years (48%). Baseline<br/>ejection fraction recorded for all patients ranges from (42% to 76%). (26 patients) had already<br/>diastolic dysfunction grade 1, but only (4 patients) had a substandard ejection fraction. (13<br/>patients) had changes in chemotherapy regimen based on ejection fraction. Group (1) was<br/>associated with a HF incidence rate (6.7%) compared to group (2) having significantly increased<br/>HF incidence rate (20%).<br/>Conclusions: Group (2) had a significant increased incidence of cardiotoxicity. Our<br/>study,among previous studies, shed a light about routine echocardiography prior to anthracycline<br/>therapy and might eventually lead to current practice guidelines modifications.<br/>Keywords: Anthracycline, cardiotoxicity, incidence, Trastuzumab, Echocardiography,<br/>prevention. |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Breast cancer |
General subdivision |
Cardiotoxicity |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Nada Akmal El kilany 150667 |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Shrouk Hassan Mahdy 155411 |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Ibrahim Mohamed Negm 155409 |
856 ## - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1SJYIqGYeAdgMBnZBzw-flddFz8i00htN/view">https://drive.google.com/file/d/1SJYIqGYeAdgMBnZBzw-flddFz8i00htN/view</a> |
Public note |
FULL TEXT PRESS HERE |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
Dewey Decimal Classification |
Koha item type |
Distinguished Graduation Projects |