35986841_10216840653711318_1105697261150535680_n

Assessment of Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients : Incidence, Risk Factors, and Prevention RS502 RSPL2.1 // GP // Prof. Dr. Soheir Aboelazm Diab // T.A. Mennat Allah Hassan Kamal (2018 - 2019) (Record no. 24970)

MARC details
000 -LEADER
fixed length control field 02996nam a22002537a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190728120708.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180715b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency MSA
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.704
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Lojaine Hesham Fawzy 150249
245 ## - TITLE STATEMENT
Title Assessment of Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients : Incidence, Risk Factors, and Prevention RS502 RSPL2.1 // GP // Prof. Dr. Soheir Aboelazm Diab // T.A. Mennat Allah Hassan Kamal (2018 - 2019)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Giza :
Name of publisher, distributor, etc. MSA,
Date of publication, distribution, etc. 2019.
300 ## - PHYSICAL DESCRIPTION
Extent 50 p.
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE
Title PHARMACY DISTINGUISHED PROJECTS 2019
500 ## - GENERAL NOTE
General note Pharmacy - Clinical Pharmacy
520 ## - SUMMARY, ETC.
Summary, etc. Background: Anthracycline-based chemotherapy has played a significant role in the<br/>treatment of various breast cancer stages with reduced rates of both relapse and mortality.<br/>However their benefits have been limited due to their adverse events ranging from<br/>myelosuppression to well-established risk of cardiotoxicity.<br/>Aim: Investigate the correlation between incidence of cardiotoxicity and risk factors in breast<br/>cancer patients treated with Anthracyclines and outline current strategies for prevention of<br/>Anthracycline induced cardiotoxicity.<br/>Subjects and Method: 60 breast cancer patients, (stages II&IIIA), with age ranging from 30<br/>to 65 years, newly diagnosed and scheduled for chemotherapy .Our study population were<br/>classified into group 1 (30 patients receiving Anthracycline-based chemotherapy) and group 2(<br/>30 patients receiving Trastuzumab combined with anthracycline-based chemotherapy).<br/>Parameters to be measured: ejection fraction, blood pressure, body mass index, and baseline<br/>heart rate to record any case of Heart Failure (HF) following anthracyclines treatment.<br/>Results: The main comorbidities related to cardiotoxicity among study population were<br/>hypertension (44%), diabetes (31%), obesity (90%), and age above 55 years (48%). Baseline<br/>ejection fraction recorded for all patients ranges from (42% to 76%). (26 patients) had already<br/>diastolic dysfunction grade 1, but only (4 patients) had a substandard ejection fraction. (13<br/>patients) had changes in chemotherapy regimen based on ejection fraction. Group (1) was<br/>associated with a HF incidence rate (6.7%) compared to group (2) having significantly increased<br/>HF incidence rate (20%).<br/>Conclusions: Group (2) had a significant increased incidence of cardiotoxicity. Our<br/>study,among previous studies, shed a light about routine echocardiography prior to anthracycline<br/>therapy and might eventually lead to current practice guidelines modifications.<br/>Keywords: Anthracycline, cardiotoxicity, incidence, Trastuzumab, Echocardiography,<br/>prevention.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Breast cancer
General subdivision Cardiotoxicity
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Nada Akmal El kilany 150667
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Shrouk Hassan Mahdy 155411
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Ibrahim Mohamed Negm 155409
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1SJYIqGYeAdgMBnZBzw-flddFz8i00htN/view">https://drive.google.com/file/d/1SJYIqGYeAdgMBnZBzw-flddFz8i00htN/view</a>
Public note FULL TEXT PRESS HERE
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Distinguished Graduation Projects
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     Centeral Library Centeral Library Soft Copy located on library Cataloge 28.07.2019   GP37PH2019Clinical Pharmacy 82194 28.07.2019 28.07.2019 Distinguished Graduation Projects