MARC details
| 000 -LEADER |
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| fixed length control field |
02776nam a22002537a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20190805094018.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190729b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
547 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Radwa Salah Mokhtar 150567 |
| 245 ## - TITLE STATEMENT |
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| Title |
Design, synthesis and biological activity of phenolic derivatives of oat active constituents // GP // Dr. Aliaa Mohammed Kamal // A.L. Enas Galal (2018 - 2019) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
GIZA |
| Name of publisher, distributor, etc. |
MSA |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
64 P. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
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| Title |
PharmaciesDISTINGUISHED PROJECTS 2019 |
| 500 ## - GENERAL NOTE |
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| General note |
Pharmacy - Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
aCaffeic aacid is a aphenolic acompound awhich acan aoccur anaturally in aplants<br/>asuch as aoat, afruit ,avegetable and acoffee abean and acan abe aobtained by<br/>aextraction amethod from it or be asynthesized by atwo aroutes afirst athe areaction of<br/>aHorner–Wadsworth–Emmons(HWE) 4<br/>The asecond aachieves aKnoevenagel and<br/>aaldol ashortenings. aIt ahas a avariety of aactivity asuch aas aantimicrobial ,<br/>aanti-inflammatory , aanti-viral , aantioxidant and aanticancer aactivity. It is amainly<br/>aused in the aester form to give the aanticancer aactivity asuch as acaffeic acid phenyl<br/>ester (CAPE) <br/>in the form of aester, it acan treat many atypes of acancer such as alung<br/>,acolon , aprostate, aleukemia and amelanoma , ait aacts as antioxidant by atwo<br/>amechanisms afree Aradical ascavengers and asometimes as metal chelators and as<br/>aanticancer by ainhibiting the anucleotide aturn over Asalvage pathway , addition of<br/>aperoxide to alipid, astrand of DNA abreak, adivisions of protein and it ainhibits<br/>5-lipoxygenase aenzyme by a awhole anon-competitive mechanism 3<br/>Our aim is to adesign new aderivatives of acaffeic acid, asynthesis of derivative of acaffeic aacid<br/>and atest the abiological aactivity of the anewly synthesized acompounds against<br/>acancer acell alines. aCaffeic aamide aderivatives were aexpected to be asynthesized<br/>athrough aformation of the aacid achloride ausing POCl3 afollowed by aamide<br/>aformation awith the ahelp of the arespective aamine. Due to the ainsolubility aof the<br/>aformed caffeic acid achloride another aamethod was devised using DCC to adirectly<br/>aacouple the aamine with caffeic acid.4-hydroxyanaline, P-toluidine, Cyclohexyl<br/>amine and M-toluidine amines used to asynthesis adifferent amide aderivatives of<br/>caffeic acid which achemopreventive anti-tumor aagents. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Design, synthesis and biological activity of phenolic |
| Chronological subdivision |
derivatives of oat active constituents |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sara Mahmoud Mohamed 151239 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Sarah Ali El sayed 152907 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Yasmena Ibrahim Salama 151173 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1EG7MX7HXGuyim3hSc8ILKuC5D7XvX_Ak/view">https://drive.google.com/file/d/1EG7MX7HXGuyim3hSc8ILKuC5D7XvX_Ak/view</a> |
| Public note |
FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Distinguished Graduation Projects |
