MARC details
000 -LEADER |
fixed length control field |
02432nam a22002537a 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190805093916.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190804b ||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Transcribing agency |
MSA |
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
Classification number |
547 |
100 ## - MAIN ENTRY--PERSONAL NAME |
Personal name |
Abdelhalim Fouad Saoud 154537 |
245 ## - TITLE STATEMENT |
Title |
Improving dermal delivery of the ketoconazole via loading into bilosomal vesicles // GP // Dr. Abdulaziz Mohsen // T.A. Pakinam Zikry // T.A. Dalia El Khayat (2018 - 2019) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
GIZA : |
Name of publisher, distributor, etc. |
MSA, |
Date of publication, distribution, etc. |
2019. |
300 ## - PHYSICAL DESCRIPTION |
Extent |
39 P. |
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
Title |
PharmaciesDISTINGUISHED PROJECTS 2019 |
500 ## - GENERAL NOTE |
General note |
Pharmacy - Organic Chemistry |
520 ## - SUMMARY, ETC. |
Summary, etc. |
The advancement in nanotechnologies issued an improvement in its application in<br/>medicine as well which is why this prospective study aims to encapsulate a medication<br/>called ketoconazole which is insoluble in water and anti-mycotic drug into a new nano-<br/>vesicles called bilosomes for attaining enhanced dermal delivery. The bilosomes is<br/>formulated from span 60, bile salt and cholesterol. In this study ketoconazole was<br/>loaded into bilosomes using a technique called ethanol injection method. As stated in<br/>23 full factorial design that is to say eight formulations form B1 to B8. The examination<br/>of the effect of variable preparations variables on bilosomes characteristics and choice<br/>of the perfect preparation was done by the utilization of a program called Design<br/>Expert®. The chosen bilosomal preparation (B8 constitutes of 112.5 milligrams of span<br/>60,37.5 milligrams of cholesterol and 40 milligrams of bile salt which is sodium<br/>cholate). Results has shown that the perfect preparation showed greater in vivo pass of<br/>the drug through the skin of the wistar rats while compared with the traditional nano<br/>vesicles like niosomes, and the suspension of this medication. Later on, in the<br/>histopathological, vivo skin studies done using male wistar rats has showed that the<br/>formulated bilosomal carrier is safe to be applied on the skin. Generally, the attained<br/>results established that bilosomal carrier could be a promising carrier for the skin<br/>delivery in the future. |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
bilosomal vesicles |
General subdivision |
the ketoconazole |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Eslam Essam El Din Abd El Monem 151093 |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Mohamed Abdelkhalek Badr 150157 |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Mohamed Hossam Abomandor 151311 |
856 ## - ELECTRONIC LOCATION AND ACCESS |
Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1YQfErOFNiB9lnxpbPyKXGB2viT5T8V4f/view">https://drive.google.com/file/d/1YQfErOFNiB9lnxpbPyKXGB2viT5T8V4f/view</a> |
Public note |
FULL TEXT PRESS HERE |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
Dewey Decimal Classification |
Koha item type |
Distinguished Graduation Projects |