35986841_10216840653711318_1105697261150535680_n

Improving dermal delivery of the ketoconazole via loading into bilosomal vesicles // GP // Dr. Abdulaziz Mohsen // T.A. Pakinam Zikry // T.A. Dalia El Khayat (2018 - 2019) (Record no. 25020)

MARC details
000 -LEADER
fixed length control field 02432nam a22002537a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190805093916.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190804b ||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency MSA
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 547
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Abdelhalim Fouad Saoud 154537
245 ## - TITLE STATEMENT
Title Improving dermal delivery of the ketoconazole via loading into bilosomal vesicles // GP // Dr. Abdulaziz Mohsen // T.A. Pakinam Zikry // T.A. Dalia El Khayat (2018 - 2019)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. GIZA :
Name of publisher, distributor, etc. MSA,
Date of publication, distribution, etc. 2019.
300 ## - PHYSICAL DESCRIPTION
Extent 39 P.
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE
Title PharmaciesDISTINGUISHED PROJECTS 2019
500 ## - GENERAL NOTE
General note Pharmacy - Organic Chemistry
520 ## - SUMMARY, ETC.
Summary, etc. The advancement in nanotechnologies issued an improvement in its application in<br/>medicine as well which is why this prospective study aims to encapsulate a medication<br/>called ketoconazole which is insoluble in water and anti-mycotic drug into a new nano-<br/>vesicles called bilosomes for attaining enhanced dermal delivery. The bilosomes is<br/>formulated from span 60, bile salt and cholesterol. In this study ketoconazole was<br/>loaded into bilosomes using a technique called ethanol injection method. As stated in<br/>23 full factorial design that is to say eight formulations form B1 to B8. The examination<br/>of the effect of variable preparations variables on bilosomes characteristics and choice<br/>of the perfect preparation was done by the utilization of a program called Design<br/>Expert®. The chosen bilosomal preparation (B8 constitutes of 112.5 milligrams of span<br/>60,37.5 milligrams of cholesterol and 40 milligrams of bile salt which is sodium<br/>cholate). Results has shown that the perfect preparation showed greater in vivo pass of<br/>the drug through the skin of the wistar rats while compared with the traditional nano<br/>vesicles like niosomes, and the suspension of this medication. Later on, in the<br/>histopathological, vivo skin studies done using male wistar rats has showed that the<br/>formulated bilosomal carrier is safe to be applied on the skin. Generally, the attained<br/>results established that bilosomal carrier could be a promising carrier for the skin<br/>delivery in the future.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element bilosomal vesicles
General subdivision the ketoconazole
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Eslam Essam El Din Abd El Monem 151093
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mohamed Abdelkhalek Badr 150157
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mohamed Hossam Abomandor 151311
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1YQfErOFNiB9lnxpbPyKXGB2viT5T8V4f/view">https://drive.google.com/file/d/1YQfErOFNiB9lnxpbPyKXGB2viT5T8V4f/view</a>
Public note FULL TEXT PRESS HERE
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Distinguished Graduation Projects
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     Centeral Library Centeral Library Soft Copy located on library Cataloge 04.08.2019   GP35PH2019 - OCHEM 82223 04.08.2019 04.08.2019 Distinguished Graduation Projects