MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03072nam a22002537a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20190805094309.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190804b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
MSA |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
547 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Israa Ali Mahmoud 155909 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
NOVEL VITAMIN D DELIVERY SYSTEM USING PAMAM G5 DENDRIMER: DEVELOPMENT AND CHARACTERIZATION // GP // Dr. Hanan El-Laithy // A.L. Omar Elkady (2018 - 2019) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
GIZA |
| Name of publisher, distributor, etc. |
MSA |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
64 P. |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
|---|
| Title |
PharmaciesDISTINGUISHED PROJECTS 2019 |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Pharmacy - Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Osteoporosis is a globally-prevalent progressive skeleton disease among geriatrics,<br/>resulting from bone remodeling imbalance and bone resorption. In Egypt, 28.4% of<br/>females and 21.9% of males are osteoporotic with brittle, fragile porous and easily-<br/>fractured bones. Unfortunately, according to the National Osteoporosis Foundation,<br/>there is no cure for osteoporosis, but oral bisphosphonates are frequently-prescribed for<br/>the management of the disease under very strict patient dosing guidelines and difficult<br/>tolerance of gastroesophageal side effects. Our research aims to develop a novel inhaled<br/>Risedronate Sodium (RS) marketed as Actonel® in combination with vitamin D using<br/>PAMAM G5 dendrimer, with less oral adverse effects and better bioavailability.<br/>PAMAM G5-RS- Vitamin D complexes were prepared and characterized for different<br/>in vitro aspects [mean size, zeta potential, entrapment efficiency (EE) %, Fourier<br/>Transform Infrared spectroscopy (FTIR) and morphological shape by Transmission<br/>Electron Microscopy (TEM)]. Preliminary aerodynamic particle size characterization<br/>on the developed complex was performed using Anderson Cascade Impactor to<br/>determine regional lung deposition.<br/>The developed PAMAM inhaled complex was compared in vivo to the oral commercial<br/>product Actonel® in induced osteoporotic female Wistar albino rats after IP daily<br/>injection of dexamethasone phosphate for 2 weeks.<br/>The developed complex revealed spherical-shaped nanoparticles with an average size<br/>of 180 nm, +0.2 mV zeta potential value which entrapped both drugs successfully.<br/>Hydrogen bonding was confirmed by the FTIR spectra between the aliphatic RS OH<br/>group as well as Vitamin D alcoholic OH group and PAMAM G5 NH2 group. The<br/>HPLC results revealed that most of the nebulized dose got deposited on the collection<br/>plate of stage 7 (0.4 - 0.7 micron) of the Anderson Cascade Impactor and the in vivo<br/>results inferred that the inhaled complex offered a more efficient therapeutic response<br/>than that of the oral one as it promoted bone mineralization and inhibited bone density<br/>loss within a short treatment period.<br/> |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
NOVEL VITAMIN D DELIVERY SYSTEM |
| General subdivision |
PAMAM G5 DENDRIMER: DEVELOPMENT |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nada Hossam Seifelnasr 155703 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nesma Hussein Ramadan 155885 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yasmine Mahmoud Al-Wakeel 155831 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="https://drive.google.com/file/d/1Tv4jcoII8U0594IY6wJKmFO3K4mAMz5S/view">https://drive.google.com/file/d/1Tv4jcoII8U0594IY6wJKmFO3K4mAMz5S/view</a> |
| Public note |
FULL TEXT PRESS HERE |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Distinguished Graduation Projects |
