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Preparing of Cyclodextrin Polymeric Nanoparticles for Enhancing Drug Bioavailability // GP // Dr. Eman Saddar // T.A. Heidi Ayman Mahmoud (2018 - 2019) (Record no. 25022)

MARC details
000 -LEADER
fixed length control field 02759nam a22002537a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20190805094529.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190804b ||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Transcribing agency MSa
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 547
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Assem Mohamed Habib 154375
245 ## - TITLE STATEMENT
Title Preparing of Cyclodextrin Polymeric Nanoparticles for Enhancing Drug Bioavailability // GP // Dr. Eman Saddar // T.A. Heidi Ayman Mahmoud (2018 - 2019)
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. GIZA :
Name of publisher, distributor, etc. MSA,
Date of publication, distribution, etc. 2019.
300 ## - PHYSICAL DESCRIPTION
Extent 62 P.
440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE
Title PharmaciesDISTINGUISHED PROJECTS 2019
500 ## - GENERAL NOTE
General note Pharmacy - Organic Chemistry
520 ## - SUMMARY, ETC.
Summary, etc. Rosuvastatin calcium is one of a statin medication, used to prevent cardiovascular disease in those at<br/>high risk and treat abnormal lipids. It is a poorly soluble drug with oral bioavailability 20% due to<br/>extensive first pass effect. The study aimed to formulate cyclo-dextrin loaded polyrotaxane<br/>nanoparticles loaded with Rosuvastatin Calcium to improve its solubility, efficacy and reduce side<br/>effects. The effects of polymers (PVP), cyclodextrin concentrations or their combinations at different<br/>polymers ratios on the drug solubility dissolution rate was studied.<br/>The Experimental studies: Polyrotaxane was prepared by dissolving drug, PVP and<br/>cyclodextrane all together. The mixture was cooled for 24 hour to allow precipitation of drug-<br/>polyrotaxane powder, then dried at at 40 oC for 24 hours. The dried powdered was weighted. The drug<br/>content of polyrotaxane was determined. 0.05 g of the prepared polyrotaxane was dissolved in 10 ml<br/>methanol, to guarantee complete drug solubility. The drug concentration was measured<br/>spectrophotometrically at wavelength 243nm. The dissolution test used to compare between the poorly<br/>soluble rosuvastatin drug and polyrotaxane. Differential scanning calorimetry test used to concern with<br/>the measurement of energy acquired or emitted by a sample of matter when it is heated or cooled. It<br/>also provides information about endothermic and exothermic processes. X- Ray powder diffraction is a<br/>technique that utilizes x- ray scattering pointed on crystals of powder to give identity and information<br/>about the crystalline structure.<br/>The Results: The powder weight was 2.8gm presents 22.85 % yield. Five mg of polyrotaxane<br/>contains 3.575 mg pure drug (71.5% drug loading and 1%.encapsulation efficiency. Polyrotaxane<br/>complex enhance both drug solubility and dissolution.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cyclodextrin Polymeric Nanoparticles
General subdivision Enhancing Drug
Chronological subdivision Bioavailability
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Rozana Akmal Kamal 150271
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Mariam Magdy Aziz 153587
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Salma Ahmed Khalifa 150747
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/1bvtCdkpfdcizPa25GxUESFBJs8XY4kcg/view">https://drive.google.com/file/d/1bvtCdkpfdcizPa25GxUESFBJs8XY4kcg/view</a>
Public note FULL TEXT PRESS HERE
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Distinguished Graduation Projects
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Shelving location Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     Centeral Library Centeral Library Soft Copy located on library Cataloge 04.08.2019   GP37PH2019 - OCHEM 82221 04.08.2019 04.08.2019 Distinguished Graduation Projects