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The role of stem cells in the treatment of diabetes mellitus دور الخلايا الجذعيه الوسيطه فى داء السكرى // GP //Dr. Shereen Mahmoud // T.A. Mariam Sabry Attia (2017-2018)

By: Mahmoud Ahmed Shawky 141379.
Contributor(s): Silvia Osama Asaad 141997 | Nardeen Maher Samy 142655.
Material type: materialTypeLabelBookPublisher: Giza : MSA 2018Description: 62 P. 30 CM.Subject(s): Pharmacy -- Biochemistry -- stem cellsDDC classification: 615 Online resources: FULL TEXT PRESS HERE Summary: Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose over produced, causing hyperglycemia. Type 1 diabetes, occur when beta cell cannot produce insulin so no activation of GLUT4 and no enter of glucose into cells. Stem cells un differentiated cells divided by mitotic cell division into symmetric division known as self- renewing and asymmetric division that differentiate inside the body into for example , Somatic cells. Stem cell is possible to identify two large potential application fields of stem cells in diabetes mellitus: The reconstruction of β cell mass, and helps in the treatment of complications. Our target, find the mechanisms responsible for the effectiveness of bone marrow-derived mesnchymal stem cells in the suppression of DM Type 1. Experimental design: Eighteen male Albino Wistar rats divided into three groups , each Group having Six Rat Group I normal not diabetic and not suffering from any biochemical disorder, Group II Rats which are STZ- induced diabetes group, Group III will be the Mesnchymal stem cells treated group MSCs (1×105 cells/rat) injected via tail veins in rats with STZ-induced diabetes. Blood glucose was measured spectrophotometry, Interleukin 6 and GLUT4 were measured by Elisa, insulin genes 1 and insulin genes 2 were measured by Real-time PCR. Insulin genes 1, insulin genes 2 and GLUT4 levels were significantly elevated in treated group compared to diabetic group (1). Interleukin 6 and blood glucose levels were significantly decreased in treated group compared to diabetic group. Mesnchymal stem cells may play an important role in treatment of T1DM.Summary: المرض السكري هو مجموعة من االضطرابات األيضية في عملية التمثيل الغذائي للكربوهيدرات التي ينتج منها الجلوكوز ، مما يسبب ارتفاع السكر في الدم. في المرضى الذين يعانون من مرض السكري من النوع 1 الذى يحدث عندما ال تستطيع خلية بيتا إنتاج األنسولين حتى ال يتم تفعيل GLUT4 وعدم دخول الجلوكوز إلى الخاليا. الخاليا الجذعية تنقسم عن طريق االنقسام الخلوي إلى قسم متماثل يعرف باسم التجديد
List(s) this item appears in: PHARMACY Distinguished Graduation Projects - Year 2017/2018
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Distinguished Graduation Projects Distinguished Graduation Projects Soft Copy located on INTERNET GP44PH2018BioChem (Browse shelf) Available 81941

Pharmacy-Biochemistry

Diabetes mellitus is a group of metabolic disorders of carbohydrate
metabolism in which glucose over produced, causing hyperglycemia. Type
1 diabetes, occur when beta cell cannot produce insulin so no activation of
GLUT4 and no enter of glucose into cells. Stem cells un differentiated cells

divided by mitotic cell division into symmetric division known as self-
renewing and asymmetric division that differentiate inside the body into

for example , Somatic cells. Stem cell is possible to identify two large
potential application fields of stem cells in diabetes mellitus: The
reconstruction of β cell mass, and helps in the treatment of complications.
Our target, find the mechanisms responsible for the effectiveness of bone
marrow-derived mesnchymal stem cells in the suppression of DM Type 1.
Experimental design: Eighteen male Albino Wistar rats divided into three
groups , each Group having Six Rat Group I normal not diabetic and not

suffering from any biochemical disorder, Group II Rats which are STZ-
induced diabetes group, Group III will be the Mesnchymal stem cells

treated group MSCs (1×105 cells/rat) injected via tail veins in rats with
STZ-induced diabetes. Blood glucose was measured spectrophotometry,
Interleukin 6 and GLUT4 were measured by Elisa, insulin genes 1 and
insulin genes 2 were measured by Real-time PCR. Insulin genes 1, insulin
genes 2 and GLUT4 levels were significantly elevated in treated group
compared to diabetic group (1). Interleukin 6 and blood glucose levels
were significantly decreased in treated group compared to diabetic group.
Mesnchymal stem cells may play an important role in treatment of T1DM.


المرض السكري هو مجموعة من االضطرابات األيضية في عملية التمثيل الغذائي للكربوهيدرات التي ينتج منها الجلوكوز
، مما يسبب ارتفاع السكر في الدم. في المرضى الذين يعانون من مرض السكري من النوع 1 الذى يحدث عندما ال
تستطيع خلية بيتا إنتاج األنسولين حتى ال يتم تفعيل GLUT4 وعدم دخول الجلوكوز إلى الخاليا. الخاليا الجذعية تنقسم
عن طريق االنقسام الخلوي إلى قسم متماثل يعرف باسم التجديد

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