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NANO-FORMULATION AND PHARMACOLOGICAL EVALUATION OF ANTI-AGING HERBAL PRODUCTS // GP //Dr. Mahitab Helmi (2018 - 2019 )

By: Mariam Akram El-Meligy 151019.
Contributor(s): [Sara Ishaq Bolis 150171 , Sherine Bahaa El-Dein 150929 , Taghreed Sameh Mahdy 150791 ].
Material type: TextTextSeries: Pharmacy DISTINGUISHED PROJECTS 2019. Publisher: Giza MSA 2019Description: 70.Subject(s): NANO-FORMULATION | ANTI-AGING HERBAL PRODUCTSDDC classification: 615.19 Online resources: FULL TEXT PRESS HERE Summary: Wrinkles are creases, folds, or ridges in the skin. After the age of 20, the skin begins to lose over time its elasticity, firmness and collagen fibers. Accordingly, wrinkles tend to occur in the areas of muscle contraction. Citrus sinensis L. belonging to family Rutaceae are widely consumed in Egypt. Citrus peels are the most important by-product of Citrus fruits. They are major sources of phenolics specially flavanones and their glycosides, which are a powerful natural antioxidant that may possess an anti-wrinkles activity. The aim of this project is to characterize the major metabolites in the 95% ethanolic extract of C. sinensis fruits peels and evaluate its antioxidant and anti-wrinkles activities. The HPLC analysis of the extract revealed that the major compounds were hesperidin and quercetin. The extract was characterized also via HPLC-MS-MS, the analysis revealed that sesamolinol and hesperidin were the major identified constituents. The antioxidant activity was evaluated using ORAC assay and the extract showed promising antioxidant activity. The in vitro anti-wrinkles activity of the extract was evaluated by screening their inhibitory activity on elastase and collagenase enzymes, the extract showed good inhibitory activity with IC50 values of 299.04 ug/ml and 188.6lug/ml respectively, which is close to the tested standards Elafin and EGCG (IC50 250.09 and 112.12 ug/ml). Thus, C. sinensis fruits peels extract can be used to develop a completely natural anti-aging herbal product with antioxidant
List(s) this item appears in: Pharmacy D. G. P 2018 / 2019
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Distinguished Graduation Projects Distinguished Graduation Projects Centeral Library
Soft Copy located on library Cataloge
GP66PH2019Pharmacognosy (Browse shelf) Available 82045

Pharmacy

Wrinkles are creases, folds, or ridges in the skin. After the age of 20, the skin begins to lose over time its elasticity, firmness and collagen fibers. Accordingly, wrinkles tend to occur in the areas of muscle contraction. Citrus sinensis L. belonging to family Rutaceae are widely consumed in Egypt. Citrus peels are the most important by-product of Citrus fruits. They are major sources of phenolics specially flavanones and their glycosides, which are a powerful natural antioxidant that may possess an anti-wrinkles activity. The aim of this project is to characterize the major metabolites in the 95% ethanolic extract of C. sinensis fruits peels and evaluate its antioxidant and anti-wrinkles activities. The HPLC analysis of the extract revealed that the major compounds were hesperidin and quercetin. The extract was characterized also via HPLC-MS-MS, the analysis revealed that sesamolinol and hesperidin were the major identified constituents. The antioxidant activity was evaluated using ORAC assay and the extract showed promising antioxidant activity. The in vitro anti-wrinkles activity of the extract was evaluated by screening their inhibitory activity on elastase and collagenase enzymes, the extract showed good inhibitory activity with IC50 values of 299.04 ug/ml and 188.6lug/ml respectively, which is close to the tested standards Elafin and EGCG (IC50 250.09 and 112.12 ug/ml). Thus, C. sinensis fruits peels extract can be used to develop a completely natural anti-aging herbal product with antioxidant

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