35986841_10216840653711318_1105697261150535680_n
Normal view MARC view ISBD view

Antihyperglycemic activity evaluation and chemical profiling of edible pericarps of phaseolus vulgaris L RSPHO 1.1 // GP // Prof. Dr. Amany El-Brairy // A.L. MahaMousa Mahmoud (2018 - 2019)

By: Abanoub Kasban Amen 151381.
Contributor(s): Amira Safwat Moussa 150727 | Dina Walied Hassan 150597 | Maryam Abdelnasser 154951.
Material type: TextTextSeries: PHARMACY DISTINGUISHED PROJECTS 2019. Publisher: Giza : MSA, 2019Description: 61 p.Subject(s): DiabetesDDC classification: 616.462 Online resources: FULL TEXT PRESS HERE Summary: Diabetes is considered a serious metabolic disorder characterized by hyperglycemia due to absolute insulin deficiency or complete destruction of pancreatic beta cells (Type 1 diabetes) and beta cells receptors resistance (Type 2 DM). Diabetes complications are peripheral vascular diseases, coronary vascular diseases and sexual dysfunction. Conventional drugs cause adverse effects and have high cost. Nowadays, herbal drugs are used due to their natural origin and affordable cost. The study aims to evaluate the antidiabetic activity of phaseolusvulgare L pericarps. Diabetes was induced through a single IP injection of 55 mg /kg of STZ and rats was randomly divided into 6 groups each contain 6 rats Group 1: Normal control (received saline), Group 2: Diabetic control, Group 3: Diabetic group received standard drug glibenclamide (600 ug /kg P.O.) , Group 4: Diabetic group received non polar fraction of phaseolus vulgaris extract (200 mg P.O.), Group 5: Diabetic group received MSCs ( 106 cell /rat IP ) and Group 6 : Diabetic group received both NPF phaseolus vulgaris and MSCs. Phaseolus vulgaris significantly decreases glucose level , MDA, cholesterol and TGs (P<0.005) and significantly increases insulin level , Nitric oxide (NO) and HDL (P<0.005).While stem cells group significantly decreases glucose level, MDA (P<0.005) and slight decrease in cholesterol and no significant decrease in TGs .Combined group shows low glucose & MDA level and increase in insulin , nitric oxide and HDL level . The study showed that NPF phaseolus vulgaris (200mg /kg), stem cells and combined have antidiabetic activity
List(s) this item appears in: Pharmacy D. G. P 2018 / 2019
Tags from this library: No tags from this library for this title. Log in to add tags.
    Average rating: 0.0 (0 votes)
Item type Current location Call number Status Date due Barcode
Distinguished Graduation Projects Distinguished Graduation Projects Centeral Library
Soft Copy located on library Cataloge
GP67PH2019-COLOGY (Browse shelf) Available 82187

Pharmacy - Pharmacology

Diabetes is considered a serious metabolic disorder characterized by hyperglycemia due to absolute
insulin deficiency or complete destruction of pancreatic beta cells (Type 1 diabetes) and beta cells
receptors resistance (Type 2 DM). Diabetes complications are peripheral vascular diseases, coronary
vascular diseases and sexual dysfunction. Conventional drugs cause adverse effects and have high cost.
Nowadays, herbal drugs are used due to their natural origin and affordable cost. The study aims to
evaluate the antidiabetic activity of phaseolusvulgare L pericarps. Diabetes was induced through a single
IP injection of 55 mg /kg of STZ and rats was randomly divided into 6 groups each contain 6 rats Group
1: Normal control (received saline), Group 2: Diabetic control, Group 3: Diabetic group received
standard drug glibenclamide (600 ug /kg P.O.) , Group 4: Diabetic group received non polar fraction of
phaseolus vulgaris extract (200 mg P.O.), Group 5: Diabetic group received MSCs ( 106 cell /rat IP ) and
Group 6 : Diabetic group received both NPF phaseolus vulgaris and MSCs. Phaseolus vulgaris
significantly decreases glucose level , MDA, cholesterol and TGs (P<0.005) and significantly increases
insulin level , Nitric oxide (NO) and HDL (P<0.005).While stem cells group significantly decreases
glucose level, MDA (P<0.005) and slight decrease in cholesterol and no significant decrease in TGs
.Combined group shows low glucose & MDA level and increase in insulin , nitric oxide and HDL level .
The study showed that NPF phaseolus vulgaris (200mg /kg), stem cells and combined have antidiabetic
activity

There are no comments for this item.

Log in to your account to post a comment.

Click on an image to view it in the image viewer