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Nanoformulation and Pharmacological Evaluation of Antiaging Herbal Product(s) (Nanostructure lipid carrier, NLC) // GP / / Dr. Reham Amer // Dr. Pakinam Zikry (2018 - 2019)

By: Ahmed Mohamed 151639.
Contributor(s): Asim Reda 151355 | Manar Tarek 150761 | Sara Yasser 151317.
Material type: TextTextSeries: PharmaciesDISTINGUISHED PROJECTS 2019. Publisher: GIZA : MSA, 2019Description: 41 P.Subject(s): Nanoformulation and Pharmacological -- (Nanostructure lipid carrier -- Antiaging Herbal Product(s)DDC classification: 547 Online resources: FULL TEXT PRESS HERE Summary: Skin aging is a complex of biological process which affected by constant exposure to ultraviolet (UV) irradiation with subsequent generation of reactive oxygen species leading to collagen deficiency and eventually skin wrinkling. Different techniques were reported for treatment; however the application of anti-aging creams is still the best choice among various treatment methods to their nourishing effect. Apart from that herbal formulation has widely demanded in the world market for its safety. In the present study lipid nanoparticles (LNPs) are used in the formulation of anti-aging Citrus Sinensis (CS) cream due to its safety and biocompatibility of its lipid components. Eight different formulations of CS-LNPs were prepared and optimized using 3 full factorial designs. Three factors were evaluated drug concentration (X1), homogenization speed (X2) and nanoparticle type (X3). Different parameters were measured including; zeta potential (ZP), polydispersity index (PDI), particle size, entrapment efficiency (EE %) and skin occlusion test. Morphological study by using scanning electron microscopes (SEM) confirms the nanometric size of the prepared formulations with spherical and smooth surface. It was suggested that the optimized formulation (F7) was found to have (245μm) particle size, (91.065%) Entrapment Efficiency, and (91.385) Occlusive effect. In vitro permeation study of the optimized formulation through synthetic membrane showed prolonged release of medication within 24 hrs. Finally, it can be concluded that the prepared anti-aging CS/NLC cream was safe, convenient, and effective carrier to deliver the herbal medication it also showed better penetration into the skin with a significant anti-aging effect thus it will be a promising product in skin care cosmetics.
List(s) this item appears in: Pharmacy D. G. P 2018 / 2019
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Soft Copy located on library Cataloge
GP34PH2019 - OCHEM (Browse shelf) Available 82210

Pharmacy - Organic Chemistry

Skin aging is a complex of biological process which affected by constant exposure to ultraviolet
(UV) irradiation with subsequent generation of reactive oxygen species leading to collagen
deficiency and eventually skin wrinkling. Different techniques were reported for treatment;
however the application of anti-aging creams is still the best choice among various treatment
methods to their nourishing effect. Apart from that herbal formulation has widely demanded in
the world market for its safety. In the present study lipid nanoparticles (LNPs) are used in the
formulation of anti-aging Citrus Sinensis (CS) cream due to its safety and biocompatibility of its
lipid components. Eight different formulations of CS-LNPs were prepared and optimized using
3 full factorial designs. Three factors were evaluated drug concentration (X1), homogenization
speed (X2) and nanoparticle type (X3). Different parameters were measured including; zeta
potential (ZP), polydispersity index (PDI), particle size, entrapment efficiency (EE %) and skin
occlusion test. Morphological study by using scanning electron microscopes (SEM) confirms the
nanometric size of the prepared formulations with spherical and smooth surface. It was suggested
that the optimized formulation (F7) was found to have (245μm) particle size, (91.065%)
Entrapment Efficiency, and (91.385) Occlusive effect. In vitro permeation study of the optimized
formulation through synthetic membrane showed prolonged release of medication within 24 hrs.
Finally, it can be concluded that the prepared anti-aging CS/NLC cream was safe, convenient,
and effective carrier to deliver the herbal medication it also showed better penetration into the
skin with a significant anti-aging effect thus it will be a promising product in skin care
cosmetics.

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