Madonna Ateya Fahem 150183 <br/><br/>
The association of genetic variants with the risk of type 2  diabetes mellitus in Egyptian population // GP // Dr. Sherine Mahmoud ( 2018 - 2019 ) 

 - Giza :  MSA   2019 
 - 42 P. 
 - PHARMACY DISTINGUISHED PROJECTS 2019 .
<br/><br/> Abstract<br/><br/>Diabetes is a disorder in carbohydrate metabolism, and has no ability to produce<br/>insulin, thus maintaining appropriate levels of glucose in the blood. Insulin is secreted<br/>by beta cells that are located inside the pancreas called carrots from the role of<br/>Langerhans.its is to stimulate cells to eat glucose until cells use this sugar-generating<br/>energy. Diabetics may have dysfunctional beta cells, leading to reduced insulin<br/>secretion or insulin-resistant muscle cells because cells cannot eat glucose. In both<br/>cases it will increase glucose in the blood, causing high blood sugar. Blood glucose<br/>may accumulate and excrete excess sugar levels in the urine. Because high levels of<br/>glucose in the urine, the amount of water excreted will increase, causing high urine<br/>volume and frequent urination, as well as feeling hungry and thirsty, also sweetened<br/>with honey, "itching, weakness, weight loss. The first type of diabetes, known as<br/>insulin-dependent diabetes, usually comes in childhood Type 2 diabetes, called<br/>insulin-dependent diabetes, occurs more after the age of forty and more common with<br/>increasing age Most cases of diabetes Type II is more common than type 1 diabetes<br/>90% of all cells are strongly linked to obesity, and diabetes is linked to the<br/>transformation of genes called KCNQ1, which plays a major role in re-polarization,<br/>which is part of the ability to work in muscle tissue. , Suggesting that this<br/>vulnerability may be behind the sensitivity to diabetes provided by the allele.The<br/>genetic mutation in SNPS (228,328 rupees and 2237,897 rupees) is caused by<br/>KCNQ1. Another gene is KCNJ11, which plays a role in the regulation of hormone<br/>secretion, for example: insulin , In beta cells. Genetic polymorphisms in this gene<br/>have been shown to be associated with increased risk of T2DM. The study is designed<br/>to detect risk factors (genetic and non-genetic) that predict the outcome of T2DM and<br/>related complications. Peripheral blood samples were collected from diabetics and<br/>natural persons. The study was conducted on 60 people. 30 control and 30 diabetes.<br/>The blood was collected after taking their consent. We will estimate the level of blood<br/>glucose and lipid form by the spectrophotometer and also use PCR technique and<br/>serialization method to determine the genetic variables in the KcnQ & KcnJ11 gene 
<br/><br/><label>Subjects--Chronological Terms: </label><br/>Genetic --Diabetes
<br/><br/><label>Dewey Class. No.: </label>615