TY  - BOOK
AU  - Petsko,Gregory A.
AU  - Ringe,Dagmar
TI  - Protein structure and function
SN  - 0878936637 (Sinauer Associates)
AV  - QP551 .P3974 2004
U1  - 572.633 22
PY  - 2004///
CY  - London, Sunderland, MA, Oxford
PB  - New Science Press, Sinauer Associates, Blackwell Pub.
KW  - Proteins
KW  - Structure
KW  - Conformation
KW  - Protein Conformation
KW  - physiology
N1  - including index; Includes bibliographical references (p. 181-188) and index
N2  - Published by New Science Press and distributed in the U.S. and Canada by Oxford University Press

This text introduces general principles of protein structure, folding, and function, then goes beyond these basics to tackle the conceptual basis of inferring structure and function from genomic sequence. It is the first book in a series, Primers in Biology, employing a modular design in which chapters are divided into topics, each occupying one two-page spread that includes the relevant text, illustrations (in full color), definitions, and references.

The book has five chapters. The first is an introduction to the principles of protein structure and folding, with emphasis on proteins' biophysical properties. The second describes the principles of the main biochemical functions of proteins, namely binding and catalysis, with a short section on the properties of structural proteins. Chapter 3 covers the regulation of protein function, containing concise descriptions of all the regulatory mechanisms that operate on proteins, from pH to phosphorylation, with several sections on protein switches based on nucleotide hydrolysis. Chapter 4 introduces the principles whereby structure and function are deduced from sequence, with illustrative examples. The final chapter addresses how data on protein structure is gathered, interpreted, and presented.

Written for upper-level undergraduates and beginning graduate students, Protein Structure and Function is also be for working scientists needing an up-to-date introduction to the field

ER  -