TY  - BOOK
AU  - Abanoub Kasban Amen 151381 
AU  - Amira Safwat Moussa 150727 
AU  - Dina Walied Hassan 150597 
AU  - Maryam Abdelnasser 154951 
TI  - Antihyperglycemic activity evaluation and chemical profiling of edible pericarps of phaseolus vulgaris L 
RSPHO 1.1 // GP // Prof. Dr. Amany El-Brairy // A.L. MahaMousa Mahmoud (2018 - 2019)
U1  - 616.462 
PY  - 2019///
CY  - Giza
PB  - MSA
KW  - Diabetes
N1  - Pharmacy - Pharmacology
N2  - Diabetes is considered a serious metabolic disorder characterized by hyperglycemia due to absolute 
insulin deficiency or complete destruction of pancreatic beta cells (Type 1 diabetes) and beta cells 
receptors resistance (Type 2 DM). Diabetes complications are peripheral vascular diseases, coronary 
vascular diseases and sexual dysfunction. Conventional drugs cause adverse effects and have high cost. 
Nowadays, herbal drugs are used due to their natural origin and affordable cost. The study aims to 
evaluate the antidiabetic activity of phaseolusvulgare L pericarps. Diabetes was induced through a single 
IP injection of 55 mg /kg of STZ and rats was randomly divided into 6 groups each contain 6 rats Group 
1: Normal control (received saline), Group 2: Diabetic control, Group 3: Diabetic group received 
standard drug glibenclamide (600 ug /kg P.O.) , Group 4: Diabetic group received non polar fraction of 
phaseolus vulgaris extract (200 mg P.O.), Group 5: Diabetic group received MSCs ( 106 cell /rat IP ) and 
Group 6 : Diabetic group received both NPF phaseolus vulgaris and MSCs. Phaseolus vulgaris 
significantly decreases glucose level , MDA, cholesterol and TGs (P<0.005) and significantly increases 
insulin level , Nitric oxide (NO) and HDL (P<0.005).While stem cells group significantly decreases 
glucose level, MDA (P<0.005) and slight decrease in cholesterol and no significant decrease in TGs 
.Combined group shows low glucose & MDA level and increase in insulin , nitric oxide and HDL level . 
The study showed that NPF phaseolus vulgaris (200mg /kg), stem cells and combined have antidiabetic 
activity

UR  - https://drive.google.com/file/d/1pbDjR76sJoUP0NpA6W-zKnfNNRvJiqm1/view
ER  -