000			02764nam a22002537a 4500
999			_c25007 _d25007
003			OSt
005			20190805094053.0
008			190801b ||||| |||| 00| 0 eng d
040			_cMSa
082			_a547
100			_aAhmed Mohamed 151639
245			_aNanoformulation and Pharmacological Evaluation of Antiaging Herbal Product(s) (Nanostructure lipid carrier, NLC) // GP / / Dr. Reham Amer // Dr. Pakinam Zikry (2018 - 2019)
260			_aGIZA : _bMSA, _c2019.
300			_a41 P.
440			_a PharmaciesDISTINGUISHED PROJECTS 2019
500			_aPharmacy - Organic Chemistry
520			_aSkin aging is a complex of biological process which affected by constant exposure to ultraviolet (UV) irradiation with subsequent generation of reactive oxygen species leading to collagen deficiency and eventually skin wrinkling. Different techniques were reported for treatment; however the application of anti-aging creams is still the best choice among various treatment methods to their nourishing effect. Apart from that herbal formulation has widely demanded in the world market for its safety. In the present study lipid nanoparticles (LNPs) are used in the formulation of anti-aging Citrus Sinensis (CS) cream due to its safety and biocompatibility of its lipid components. Eight different formulations of CS-LNPs were prepared and optimized using 3 full factorial designs. Three factors were evaluated drug concentration (X1), homogenization speed (X2) and nanoparticle type (X3). Different parameters were measured including; zeta potential (ZP), polydispersity index (PDI), particle size, entrapment efficiency (EE %) and skin occlusion test. Morphological study by using scanning electron microscopes (SEM) confirms the nanometric size of the prepared formulations with spherical and smooth surface. It was suggested that the optimized formulation (F7) was found to have (245μm) particle size, (91.065%) Entrapment Efficiency, and (91.385) Occlusive effect. In vitro permeation study of the optimized formulation through synthetic membrane showed prolonged release of medication within 24 hrs. Finally, it can be concluded that the prepared anti-aging CS/NLC cream was safe, convenient, and effective carrier to deliver the herbal medication it also showed better penetration into the skin with a significant anti-aging effect thus it will be a promising product in skin care cosmetics.
650			_aNanoformulation and Pharmacological _x(Nanostructure lipid carrier _yAntiaging Herbal Product(s)
700			_aAsim Reda 151355
700			_aManar Tarek 150761
700			_aSara Yasser 151317
856			_uhttps://drive.google.com/file/d/1wyhUy9j78z2i0OHpOvKrd7k1dmzM3QAr/view _zFULL TEXT PRESS HERE
942			_2ddc _cD.GP