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Cytotoxic and Biomolecular Study of Five Plant Extracts Against Different Human Cancer Cell Lines // GP // Prof. Ayman Diab // Dr. Gehan Safwat // Dr. Salwa El-Hallouty (2017-2018) الدراسة السمية والجزيئية للخاليا من خمس مستخلصات نباتية ضد خطوط الخاليا السرطانية البشرية المختلفة

By: Ezzeldin Nasser Elhawary 154093.
Material type: materialTypeLabelBookPublisher: Giza MSA 2018Description: 74 P. 30 CM.Subject(s): -- Medical Biotechnology | Biomolecular | Cytotoxic | BiotechnologyDDC classification: 612 Online resources: FULL TEXT PRESS HERE Summary: Natural products offer a wide variety of chemical structures with different biological activities that can be used for the development of novel drugs. Around 60% of the current anticancer drugs were isolated from natural products. In this study, it is attempted to exploit five plant extracts, Euphorbia hierosolymitana (herb), Sapium sebifera (branch), Cordyline fruticosa (leaf and branch), Dracerna marginata (bark) and Dracaena marginata (leaf and branch), and show their cytotoxic activities on different human cancer cell line including breast carcinoma (MCF-7), hepatocellular carcinoma (HepG2), colon carcinoma (HCT116) and prostate cancer (PC3), and normal skin cell line (BJ-1). Methanol extracts of these plants underwent MTT cytotoxic assay and found that E. hierosolymitana selectively inhibited HCT116 cell proliferation with IC50 of 4.22 μg/ml, both Dracaena marginata extracts showed moderate cytotoxicity on MCF-7 with IC50 of 22.4 and 48.2 μg/ml, respectively. The remaining two extracts showed minimal to insignificant percentage inhibition on all
List(s) this item appears in: BIOTECHNOLOGY Distinguished Graduation Projects - Year 2017/2018
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Biotechnology

Natural products offer a wide variety of chemical structures
with different biological activities that can be used for the
development of novel drugs. Around 60% of the current
anticancer drugs were isolated from natural products. In this study, it is attempted
to exploit five plant extracts, Euphorbia hierosolymitana (herb), Sapium sebifera
(branch), Cordyline fruticosa (leaf and branch), Dracerna marginata (bark) and
Dracaena marginata (leaf and branch), and show their cytotoxic activities on
different human cancer cell line including breast carcinoma (MCF-7), hepatocellular
carcinoma (HepG2), colon carcinoma (HCT116) and prostate cancer (PC3), and
normal skin cell line (BJ-1). Methanol extracts of these plants underwent MTT
cytotoxic assay and found that E. hierosolymitana selectively inhibited HCT116 cell
proliferation with IC50 of 4.22 μg/ml, both Dracaena marginata extracts showed
moderate cytotoxicity on MCF-7 with IC50 of 22.4 and 48.2 μg/ml, respectively. The
remaining two extracts showed minimal to insignificant percentage inhibition on all

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