Abstract

Diabetes is a disorder in carbohydrate metabolism, and has no ability to produce
insulin, thus maintaining appropriate levels of glucose in the blood. Insulin is secreted
by beta cells that are located inside the pancreas called carrots from the role of
Langerhans.its is to stimulate cells to eat glucose until cells use this sugar-generating
energy. Diabetics may have dysfunctional beta cells, leading to reduced insulin
secretion or insulin-resistant muscle cells because cells cannot eat glucose. In both
cases it will increase glucose in the blood, causing high blood sugar. Blood glucose
may accumulate and excrete excess sugar levels in the urine. Because high levels of
glucose in the urine, the amount of water excreted will increase, causing high urine
volume and frequent urination, as well as feeling hungry and thirsty, also sweetened
with honey, "itching, weakness, weight loss. The first type of diabetes, known as
insulin-dependent diabetes, usually comes in childhood Type 2 diabetes, called
insulin-dependent diabetes, occurs more after the age of forty and more common with
increasing age Most cases of diabetes Type II is more common than type 1 diabetes
90% of all cells are strongly linked to obesity, and diabetes is linked to the
transformation of genes called KCNQ1, which plays a major role in re-polarization,
which is part of the ability to work in muscle tissue. , Suggesting that this
vulnerability may be behind the sensitivity to diabetes provided by the allele.The
genetic mutation in SNPS (228,328 rupees and 2237,897 rupees) is caused by
KCNQ1. Another gene is KCNJ11, which plays a role in the regulation of hormone
secretion, for example: insulin , In beta cells. Genetic polymorphisms in this gene
have been shown to be associated with increased risk of T2DM. The study is designed
to detect risk factors (genetic and non-genetic) that predict the outcome of T2DM and
related complications. Peripheral blood samples were collected from diabetics and
natural persons. The study was conducted on 60 people. 30 control and 30 diabetes.
The blood was collected after taking their consent. We will estimate the level of blood
glucose and lipid form by the spectrophotometer and also use PCR technique and
serialization method to determine the genetic variables in the KcnQ & KcnJ11 gene